Genetic risk prediction of knee osteoarthritis is dependent on age
نویسندگان
چکیده
منابع مشابه
Previous Pregnancies and the Subsequent Risk of Knee Osteoarthritis
Background: Osteoarthritis of the knee is a major problem and one of the most causes of disability in the elderly. Woman tending to have more frequent and more severe evidence of knee osteoarthritis. Because of the possibility, that hormonal changes may influence the disease, the present study was designed to investigate the association between pregnancies and osteoarthritis of the knee. Metho...
متن کاملGenetic Polymorphisms of Interleukin-16 and Risk of Knee Osteoarthritis
BACKGROUND Interleukin-16 (IL-16), a pleiotropic cytokine, plays a fundamental role in inflammatory diseases. This study investigates the association between IL-16 polymorphisms and the risk of knee osteoarthritis (OA) in a Chinese population. METHODS The IL-16 rs11556218, rs4072111, and rs4778889 polymorphisms were determined in 150 knee OA cases and 147 healthy controls through polymerase c...
متن کاملKnee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I
Osteoarthritis (OA) a common disease of aged population and one of the leading causes of disability. Incidence of knee OA is rising by increasing average age of general population. Age, weight, trauma to joint due to repetiting movements in particular squatting and kneeling are common risk factors of knee OA. Several factors including cytokines, leptin, and mechanical forces are pathogenic fact...
متن کاملEffect of age and osteoarthritis on knee proprioception.
OBJECTIVE To test the hypotheses that 1) knee position sense declines with age; 2) patients with osteoarthritis (OA) have worse knee position sense than elderly controls; and 3) knee position sense is correlated with functional status. METHODS The threshold for detection of knee joint displacement was measured in 30 patients with bilateral knee OA (Kellgren/Lawrence grade > or =2 in both knee...
متن کاملPrediction model for knee osteoarthritis based on genetic and clinical information
INTRODUCTION Osteoarthritis (OA) is the most common bone and joint disease influenced by genetic and environmental factors. Recent association studies have uncovered the genetic factors behind OA, its susceptibility genes, which would enable us to predict disease occurrence based on genotype information. However, most previous studies have evaluated the effects of only a single susceptibility g...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2012
ISSN: 1063-4584
DOI: 10.1016/j.joca.2012.02.309